Team news from the beeb:
Motherwell have concerns over Ross Forbes, John Sutton, Jim O'Brien and Giles Coke as the quartet missed Monday training with "heavy knocks".
Shaun Hutchinson could return from an ankle injury but Paul Slane is still out following calf surgery.
Inverness are without injured forwards Dougie Imrie and Eric Odhiambo.
Manager Terry Butcher may be tempted to ring the changes after a disappointing display in the 1-1 draw at Airdrie United on Saturday.
Motherwell (from): Ruddy, Moutaouakil, Craigan, Saunders, Reynolds, Hammell, Hateley, Coke, Forbes, O'Brien, Murphy, Sutton, Kosiorowski, Jutkiewicz, Jennings, Lasley.